NovaSyn® TG Amino Resin (130 µm): Macroporous Resin for Fmoc-Based Peptide Synthesis
NovaSyn® TG Amino Resin is a macroporous polyethylene glycol (PEG)-grafted polystyrene resin functionalized with primary amino groups. Designed specifically for Fmoc solid-phase peptide synthesis (SPPS), this resin features uniform spherical beads (~130 µm) and excellent swelling characteristics in both polar and nonpolar solvents. The PEG grafting dramatically improves solvation and reagent accessibility, making it ideal for synthesizing long, hydrophobic, or aggregation-prone peptides.
The free amino groups on the resin enable custom first amino acid attachment, giving chemists flexibility to design C-terminal carboxylic acid peptides tailored to their synthesis goals.
Specifications
Matrix: PEG-grafted polystyrene (NovaSyn® TG)
Functional Group: Primary amine (–NH₂)
Bead Size: ~130 µm
Loading: 0.2–0.4 mmol/g (typical)
Swelling: Excellent in DMF, DCM, NMP, MeOH
Compatible Chemistry: Fmoc/tBu-based SPPS
Final Peptide Terminus: Dependent on linker/amino acid used
Cleavage: Based on the installed linker (e.g., Wang, Rink, etc.)
Key Features
PEG-Grafted Macroporous Structure: Enhances reagent diffusion and swelling
Customizable: Free amino groups allow attachment of any first residue or linker
High Solvent Compatibility: Performs well in both polar and nonpolar solvents
Ideal for Difficult Sequences: Long, hydrophobic, or aggregation-prone peptides
Fmoc-Compatible: Fully suited for modern SPPS workflows
Applications
Custom C-terminal acid peptide synthesis
Attachment of custom linkers or functional handles
Synthesis of challenging or long peptide sequences
Convergent synthesis strategies with fragment condensation
Peptide–drug conjugates and modified peptide systems
Attachment Example (Workflow)
Swelling: Resin is swollen in DMF or DCM
First amino acid coupling: Activated with DIC/HOBt, PyBOP, or similar reagents
Capping (optional): Unreacted amino groups can be capped with acetic anhydride
SPPS cycles: Standard Fmoc deprotection and elongation steps follow
Cleavage: Based on the nature of the attached linker
Handling & Storage
Store dry in a sealed container away from moisture and light
Swell in DMF, DCM, NMP, or other compatible solvents prior to use
Stable under standard SPPS conditions
Avoid prolonged exposure to strong acids or bases unless intended for cleavage
Comparison with Other Amino Resins
| Resin | Matrix Type | Loading | Best Use |
|---|---|---|---|
| NovaSyn TG Amino | PEG-grafted PS | ~0.2–0.4 mmol/g | Long/hydrophobic peptides, difficult sequences |
| Aminomethyl PS Resin | Polystyrene | ~1.0 mmol/g | General SPPS, custom C-terminal acids |
| Tentagel® NH₂ Resin | PEG-PS (swelling in aqueous media) | ~0.2–0.3 mmol/g | Peptides in water-compatible systems |
Conclusion
NovaSyn® TG Amino Resin (130 µm) offers excellent performance for custom and advanced peptide synthesis, particularly where peptide solubility and chain accessibility are concerns. Its macroporous PEG-PS structure and free amino functionality make it a flexible and high-efficiency choice for modern Fmoc-SPPS.
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